Lasers and Neurodegenerative Conditions (Dementia / Parkinsons)

Harvard, Univ Toronto, and Boston Med demonstrate how lasers improve brain wave function, cognition, and memory in Alzheimer’s patients

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670 nm laser light and EGCG complementarily reduce amyloid-β aggregates in human neuroblastoma cells: basis for treatment of Alzheimer’s disease?
J Neuroinflammation, 2012
Low-level laser therapy regulates microglial function through Src-mediated signaling pathways: implications for neurodegenerative diseases. There was a significant increase in cell numbers in response to laser irradiation. Laser irradiation significantly increased ATP levels in Aβ(42)-free cells.
Neuroscience, 2010
Our data showed that laser light at 632.8 nm suppressed Aβ-induced superoxide production, colocalization between NADPH oxidase gp91(phox) and p47(phox) subunits, phosphorylation of cPLA(2,) and the expressions of IL-1β and iNOS in primary astrocytes. We demonstrated for the first time that 632.8 nm laser was capable of suppressing cellular pathways of oxidative stress and inflammatory responses critical in the pathogenesis in Alzheimer’s Disease (AD). This study should prove to provide the groundwork for further investigations for the potential use of laser therapy as a treatment for AD.
Near-infrared light via light-emitting diode treatment is therapeutic against rotenone- and 1-methyl-4-phenylpyridinium ion-induced neurotoxicity
Neuroscience, 2008
These results strongly suggest that LED treatment may be therapeutic to neurons damaged by neurotoxins linked to Parkinson’s disease by energizing the cells and increasing their viability.
Turning On Lights to Stop Neurodegeneration: The Potential of Near Infrared Light Therapy in Alzheimer’s and Parkinson’s Disease
Front Neurosci, 2016
Alzheimer’s and Parkinson’s develop after a progressive death of many neurons in the brain. Red to infrared light therapy (λ = 600-1070 nm), and in particular light in the near infrared (NIr) range, is emerging as a safe and effective therapy that is capable of arresting neuronal death. Previous studies have used NIr to treat tissue stressed by hypoxia, toxic insult, genetic mutation and mitochondrial dysfunction with much success. Here we propose LASER therapy as a neuroprotective or disease-modifying treatment for Alzheimer’s and Parkinson’s patients.
Turning On Lights to Stop Neurodegeneration: The Potential of Near Infrared Light Therapy in Alzheimer’s and Parkinson’s Disease
Frontiers in neuroscience, 2015
Near Infrared (NIr) LASER has the potential to be neuroprotective. A growing body of pre-clinical evidence indicates that NIr therapy slows or stops disease pathology. This is something that the current mainstay of treatments for both diseases—drug therapy—does not do. Although in its infancy, with the bulk of results still at the pre-clinical “proof of concept” stage, NIr therapy has the potential to develop into a safe and effective neuroprotective treatment for patients with Alzheimer’s and Parkinson’s disease (and presumably other neurodegenerative diseases such multiple sclerosis and amyotrophic lateral sclerosis).
Photobiomodulation enhances nigral dopaminergic cell survival in a chronic MPTP mouse model of Parkinson’s disease
Parkinsonism Relat Disord, 2012
Photobiomodulation enhances nigral dopaminergic cell survival in a chronic MPTP mouse model of Parkinson’s disease. “We have shown previously that photobiomodulation or near-infrared light (NIr) treatment protects dopaminergic cells of the substantia nigra pars compacta (SNc).. model of Parkinson’s disease (PD). In this study, we tested the protective and rescue action of NIr treatment in a chronic MPTP model. In summary, exposure to NIr either at the same time or well after chronic induced parkinson’s disease saved many Substantia Nigra dopaminergic cells from degeneration.”
Photobiomodulation with near infrared light mitigates Alzheimer’s disease-related pathology in cerebral cortex – evidence from two transgenic mouse models
Alzheimer’s Research & Therapy, 2014
Potential as an effective, minimally-invasive intervention for mitigating, and even reversing, progressive cerebral degenerations. NIr treatment was associated with a reduction in the size and number of amyloid-β plaques in the neocortex and hippocampus.
Low-level light therapy of the eye and brain
Eye Brain, 2011
Near-infrared light via light-emitting diode treatment is therapeutic against rotenone- and 1-methyl-4-phenylpyridinium ion-induced neurotoxicity. Since mitochondrial dysfunction plays a key role in neurodegeneration, LLLT has potential significant applications against retinal and brain damage by counteracting the consequences of mitochondrial failure. Upon transcranial delivery in vivo, LLLT induces brain metabolic and antioxidant beneficial effects, as measured by increases in cytochrome oxidase and superoxide dismutase activities. Increases in cerebral blood flow and cognitive functions induced by LLLT have also been observed in humans. Importantly, LLLT given at energy densities that exert beneficial effects does not induce adverse effects. This highlights the value of LLLT as a novel paradigm to treat visual, neurological, and psychological conditions, and supports that neuronal energy metabolism could constitute a major target for neurotherapeutics of the eye and brain.